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[This article belongs to Volume - 57, Issue - 05]

Abstract : Watermelon (Citrullus lanatus) is a species of Cucurbitaceae. It is abundant in summer, rich in nutrition, and attractive to consumers with great economic benefits. The present study aims to evaluate the in vitro antioxidant and anti-inflammatory activities of the ethanolic extract from watermelon flesh. The antioxidant activity was examined using the scavenging tests against DPPH radicals, hydroxyl radicals and hydrogen peroxide, chelation of iron and β-cartotene bleaching assays. In vitro anti-inflammatory activity was tested by egg albumin denaturation test. Results showed that watermelon ethanolic extract had good scavenging activity with IC50 values of 2.98±0.103 mg/ml, 7.91 ±0.27 mg/ml and 16.64 ± 0.325 mg /ml in DPPH, hydroxyl and hydrogen peroxide scavenging assays, respectively. The chelating ability of C.lanatus noticed an IC50 of 0.54±0.04 mg / ml  mg/ml compared to EDTA. In the β-carotene bleaching test, watermelon extract displayed a moderate inhibitory activity of lipid peroxidation with values of 43.09±0.16 % which is less effective compared to BHT (97.95%). The inhibition rate of egg albumin denaturation for C.lanatus increased gradually with concentration. Significantly higher inhibition of 69.89±0.67 % was showed at the concentration of 1 mg/ml. This study showed that watermelon could be a promising anti-inflammatory agent and provided evidence that its consumption is a potential source of antioxidant which have many benefits towards human health.