Abstract : The study examines the intricate relationship between perceived social support and psychological well-being, with a particular focus on the moderating effects of self-esteem, social interactions, and social comparison. While digital media has revolutionized social connectivity, gaps remain in understanding its dual role in fostering mental health and exacerbating psychological distress. The study employs a quantitative research methodology with a survey-based approach targeting Malaysian social media users to investigate these dynamics. Structural equation modeling (SEM) and reliability measures reveal significant mediating effects of perceived social support on mental health, emphasizing its potential to buffer stress and enhance psychological resilience. Findings highlight how supportive digital interactions can mitigate the adverse impacts of upward social comparisons while promoting self-esteem and overall well-being. The study contributes novel insights into how perceived social support interacts with digital engagement to shape mental health outcomes, integrating both traditional and virtual support systems. Results indicate that perceived social support substantially improves psychological well-being and moderates the adverse effects of social comparison on self-esteem. Additionally, while social media platforms provide avenues for emotional support and social validation, overreliance on virtual interactions can exacerbate dependency and reduce real-world connections. The study underscores the necessity for balanced engagement strategies to maximize the positive aspects of digital interactions while minimizing risks. Limitations include the geographically constrained sample and a reliance on self-reported data, which may introduce bias. Future research should explore longitudinal and experimental designs to establish causal relationships and extend findings to diverse populations. The implications of this study are far-reaching, offering valuable guidance for mental health interventions and digital platform design, fostering a supportive online environment for improved mental well-being.