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[This article belongs to Volume - 57, Issue - 01]

Abstract : Classical pharmacopoeia is replete with compounds that show therapeutic potential, including the ability to inhibit enzymes associated with specific diseases. The aim of this study was to evaluate the in vitro neuroprotective effects of extracts derived from the leaves of Arctium minus subsp. atlanticum, commonly known as "lesser burdock", an indigenous plant found in Algeria. The extracts were obtained using ethyl acetate, water/methanol, and aqueous extraction methods, and their efficacy against Alzheimer's disease (AD) was assessed. Different extracts were prepared by maceration or decoction of the plant leaves. A colorimetric approach was employed to measure the inhibitory effect on the enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Among the tested extracts, the ethyl acetate extract (EAE) demonstrated the highest anticholinesterase activity. The anti-BChE test revealed an IC50 value of 105±94 µg/mL. Additionally, a positive correlation was observed between the significant anticholinesterase activity and the type of extract. This study validates the anticholinesterase properties of Algerian Arctium minus subsp. atlanticum, suggesting that these extracts could be valuable in combating Alzheimer's disease and serve as a potential natural resource in the fight against neurodegeneration of this kind.