Abstract : The study explores the complex relationship between self-esteem, social support, and digital health engagement. It examines how self-esteem influences emotional, cognitive, and social well-being, and the role of social support in enhancing self-esteem. Additionally, it investigates how digital health platforms impact self-esteem and mental health outcomes. The study addresses gaps in existing research, particularly in non-Western cultural contexts, and emphasizes the role of resilience in moderating the effects of digital health on mental well-being. This research employs a quantitative approach within a positive framework to investigate the relationship between digital health engagement, self-esteem, perceived social support, and psychological well-being among 400 users. A questionnaire survey was administered using Google Forms to collect data from a purposive sample of digital health users. The study analyzes these data to test hypotheses regarding the influence of self-esteem and perceived social support on psychological well-being, with digital health engagement as a potential mediator. The study found significant positive relationships between self-esteem, perceived social support, and perceived well-being. Perceived social support was identified as a strong predictor of perceived well-being (β = 0.605, p = 0.000), while self-esteem positively influenced both perceived social support (β = 0.103, p = 0.007) and perceived well-being (β = 0.071, p = 0.022). The collinearity assessment showed no issues, with all variance inflation factors (VIFs) below the threshold of 3, indicating that multicollinearity was not a concern in the model. Furthermore, the mediation analysis revealed that perceived social support partially mediates the relationship between self-esteem and perceived well-being (VAF = 46.62%, p = 0.008), suggesting that while social support plays a significant role, other factors likely contribute to the relationship. All hypotheses in the study were supported, emphasizing the importance of fostering self-esteem and social support to improve mental health and well-being. These findings highlight the potential of digital health interventions in enhancing psychological factors to promote overall well-being. Self-esteem significantly enhances psychological well-being, influencing mental health positively. Recommendations for improving mental health include implementing intervention programs in schools and workplaces, using cognitive-behavioral techniques, and promoting digital health literacy. The implication of the study highlights the need for incorporating self-esteem into mental health interventions, emphasizing the role of digital health tools in promoting well-being. However, limitations include its cross-sectional design, reliance on self-report measures, and an urban-focused sample, which restricts generalizability. Future research should explore longitudinal studies, the impact of digital health tools, and self-esteem in vulnerable groups.