Abstract : Phenolic compounds including flavonoids and phenolic acids are plants secondary metabolites. Due to their capacity to act as antioxidant agents, there is a growing importance to use those components in traditional medicine. The aim of this study was to evaluate the chemical composition, the antioxidant activity and the anti inflammatory effect of the aqueous extract of Curcuma longa (CLAE). Total phenolic, flavonoid and tannins content in the extract were determined by a colorimetric method. The extract was subjected to assess antioxidant potential using various in vitro systems such as DPPH, β-carotene bleaching assay, free hydroxyl radicals and peroxide dismutase (SOD). In vitro anti-inflammatory activity of CLAE was evaluated by bovine serum albumin denaturation and egg albumin denaturation method at different concentrations. The extract exhibits anti-inflammatory activity in a concentration-dependent manner. In bovine serum albumin denaturation, at concentrations of 2 mg/mL, the extract showed 79.80%. In conclusion, these results demonstrated that Curcuma longa aqueous extract have a notable antioxidant activity and anti-inflammatory effects and may have some clinical benefits.