The prevalence of type 2 diabetes mellitus is increasing rapidly in industrialized countries, and adrenal glucocorticoids may intensify this disease. We sought to assess the relationship between diabetes-associated metabolic disturbances, cortisol concentrations and cholesterol levels in patients with type 2 diabetes. We investigated 80 women volunteered. The target population comprised 40 control And 40 with a type 2 diabetes. Clinical variables associated with diabetes were measured and correlated with cortisol concentrations and cholesterol levels. Stress will increase the cortisol levels. Under stress, cortisol delivers glucose to the Body to help the fight-or flight mechanism function properly. If cortisol is consistently doing this, bloodsugar levels remain constantly high, which can lead to not only hypo/hyperglycemia and diabetes but also elevated cholesterol levels. The degree of severity of several clinical measures of type 2 diabetes correlates with cortisol concentrations and cholesterol levels. Moreover, the results provide evidence for a positive relationship between metabolic disturbances and cortisol concentrations that are within the accepted normal range.